NMN (Nicotinamide Mononucleotide)
energy
NMN is a naturally occurring form of vitamin B3 that serves as a direct precursor to NAD+ — a coenzyme required for hundreds of cellular processes including energy production, DNA repair, and the function of longevity-associated enzymes called sirtuins. NAD+ levels naturally decline with age, and that decline is associated with reduced cellular energy, increased inflammation, and various age-related changes in function.
NMN offers a direct route to supporting those falling NAD+ levels. After you take it, NMN is absorbed into the bloodstream and converted to NAD+. We use SIRTality® β-Nicotinamide Mononucleotide (NMN), which carries an accepted new dietary ingredient notification (NDIN) — lawfully marketed as a dietary supplement in the U.S. At 500mg, our dose reflects the amounts used in human clinical research — a meaningful investment in your cellular energy infrastructure.
The statements on this page have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
NMN (Nicotinamide Mononucleotide) Benefits — What Studies Found
Your cells produce less energy every year after 30. NMN supplies the raw material to help rebuild what time takes.
We included NMN because cellular energy is foundational to vitality. Every function in your body — from physical performance to cognitive clarity to recovery — depends on cellular energy production. And the research is starting to show real, measurable results.
In a 60-day RCT, 300mg/day NMN raised blood NAD+/NADH by 38% vs baseline — the placebo group saw 14.3%, making the net advantage roughly 24 percentage points (Huang et al., 2022). A separate trial in older men found NMN improved gait speed and grip strength, though these improvements were nominally significant and need validation in larger studies (Igarashi et al., 2022). These aren’t theoretical — they’re measured outcomes from controlled human studies.
Most men’s vitality supplements focus on testosterone or adaptogens while ignoring the cellular machinery that powers everything. At 500mg, our dose sits comfortably within the 250–1,200mg window used across six published human RCTs — above the 300mg shown to raise NAD+ by 38%, without pushing to the highest doses studied. This isn’t a token amount — it’s a meaningful investment in your cellular energy infrastructure.
Why a 500mg dose of NMN (Nicotinamide Mononucleotide)
Human studies on NMN use doses ranging from 250mg to 1200mg daily. We chose 500mg — a substantial dose that provides meaningful NAD+ support while staying within the studied range.
- Substantial, Studied Dose 500mg sits within the 250-1200mg range used in human NMN research — above the 300mg shown to raise NAD+, without pushing to the highest doses studied.
- Direct NAD+ Precursor NMN is the most direct dietary precursor to NAD+, the coenzyme required for cellular energy production and DNA repair.
- Sized for a Full Formula Meaningful enough to support NAD+ levels without dominating the formula's capsule budget.
- Human-Trial Validated Range Oral NMN at similar doses has been confirmed to raise blood NAD+ levels in published human studies.
Dosing in the Research Range
Human studies use 250–1200mg daily. Our 500mg provides substantial NAD+ support within that range.
NAD+ powers cellular energy, DNA repair, and the enzymes that maintain you — and it drops every year after 30. NMN rebuilds the supply.
01
Physical Performance in Older Adults
Kim M, et al. (2022). Nutrients.
Source
Physical Performance in Older Adults
Kim M, et al. (2022). Nutrients. Source
A 12-week randomized, double-blind study in 108 older Japanese adults found NMN supplementation improved lower limb function (sit-to-stand test, effect size d=0.72) and reduced drowsiness (d=0.64), with the strongest effects from afternoon dosing.
02
NAD+ Elevation Confirmed
Okabe K, et al. (2022). Frontiers in Nutrition.
Source
NAD+ Elevation Confirmed
Okabe K, et al. (2022). Frontiers in Nutrition. Source
Human studies confirm that oral NMN supplementation successfully increases blood NAD+ levels. This is the foundational mechanism for all of NMN’s potential benefits—and it works.
03
Muscle Function in Healthy Older Men
Igarashi M, et al. (2022). NPJ Aging.
Source
Muscle Function in Healthy Older Men
Igarashi M, et al. (2022). NPJ Aging. Source
Chronic NMN supplementation elevated blood NAD+ levels and altered muscle function in healthy older men. The study demonstrated that oral NMN can affect relevant metabolic parameters.
04
Cardiovascular Markers
Katayoshi T, et al. (2023). Scientific Reports.
Source
Cardiovascular Markers
Katayoshi T, et al. (2023). Scientific Reports. Source
A 12-week RCT found NMN supplementation (250mg/day) tended to reduce arterial stiffness in healthy middle-aged adults, though the overall result was not statistically significant. Significant reductions were observed in subgroups with above-average BMI or blood glucose.
05
38% NAD+ Increase in 60 Days
Huang H, et al. (2022). Frontiers in Aging.
Source
38% NAD+ Increase in 60 Days
Huang H, et al. (2022). Frontiers in Aging. Source
A 60-day double-blind RCT in 66 healthy adults (40–65) found 300mg/day NMN raised serum NAD+/NADH by 38% compared to baseline, versus 14.3% in the placebo group (net advantage ~24 percentage points). Increases were already measurable at 11.3% by day 30.
06
Dose-Response NAD+ Elevation
Yi L, et al. (2023). GeroScience.
Source
Dose-Response NAD+ Elevation
Yi L, et al. (2023). GeroScience. Source
An RCT in 80 middle-aged adults tested three NMN doses over 60 days. All groups showed significant NAD+ increases — the 300mg group rose from 11.8 to 32.6 nM, with higher doses showing even larger gains.
Published Research
51 studiesEvery claim we make is grounded in peer-reviewed research. Tap any study to read the abstract.
Our Assessment: NMN (Nicotinamide Mononucleotide)
NAD+ elevation in humans is confirmed and the mechanism is sound. Early trials are promising for physical performance, but long-term human data is still limited. We included it because the science is compelling, not because it's settled.
- NMN successfully raises NAD+ levels in humans—this is well-established
- NAD+ decline with age is real and documented
- The mechanisms connecting NAD+ to cellular function are understood
- Short-term safety appears excellent
- Long-term human studies (most trials are 6-12 weeks)
- Whether NAD+ elevation translates to clinically meaningful outcomes in diverse populations
- Optimal dosing for different goals and ages
- Whether impressive animal results fully translate to humans
How NMN Fits the Formula
No ingredient works alone. NMN was chosen because it amplifies — and is amplified by — specific formula partners.
PQQ
NMN provides raw material for NAD+ production. PQQ promotes the creation of new mitochondria. Together, they address cellular energy from two angles: more NAD+ (the fuel) and more mitochondria (the engines).
Safety and Precautions
Always consult with a healthcare professional before starting any new dietary supplement, especially if you have an existing medical condition or take prescription medications.
