+1525(OH)D, ng/mL vs Placebo (12 Weeks)
In a 12-week double-blind, placebo-controlled trial of 200 men aged 18–69 whose vitamin D was below 30 ng/mL, 20,000 IU of vitamin D3 once a week (2,857 IU a day, close to our 3,000 IU) raised median blood 25(OH)D from 21 to 39 ng/mL, while placebo went from 21 to 26 ng/mL (192 analysed). The difference between groups, adjusted for baseline, was 15.0 ng/mL (95% CI 12.5–17.5, p<0.001). The same trial found no effect on total testosterone, free testosterone or SHBG, either in men with normal testosterone or in men with low testosterone. Funded by the Austrian National Bank; the manufacturer supplied the drops and placebo.